Persistent pain involves more than just hurting. Individuals experiencing pain generally feel depression, sadness, and exhaustion. This is said to be one reason due to which opioids can be so addictive; they just don’t reduce the pain but make individuals feel joyous as well.
What if it was possible to create a pain killer that might limit the negative emotions linked with pain without leading to euphoria? Researchers from the Washington University School of Medicine, St. Louis, proclaimed that they have taken an initiative to achieve this goal. Researching on rodents, they have demonstrated the ability to block receptors in the brain causing the emotional components of pain and reinstate the animal’s motivation. The findings of the latest research, can be accessed in the journal Neuron, might lay the basis for the development of novel, less addictive approaches for treating pain.
On a similar note, a research team recently reported the foremost proof in their research that the human hippocampus is essential for future planning. The findings, open for access in the journal Neuron, associate its long-established part in memory with our capability to employ our knowledge for planning the future consequences of our actions.
The results have propositions for the way we think about difficulties that influence the hippocampus, such as Alzheimer’s disease, as not just influencing memory and also decision-making. The work focuses on the hippocampal “cognitive map.” This map is said to be the spatial localization system of the brain. This system was discovered by John O’Keefe from the University College of London, who is the winner of the 2014 Nobel Prize in Medicine or Physiology. The hippocampal cognitive map has been long considered for permitting us to “mentally simulate” the prospect results of our actions as we plan into the future. However, there had earlier been no direct proof in humans that the hippocampus is really essential for planning.